cytokine storm

noun

plural cytokine storms
: the uncontrolled, sometimes life-threatening, excessive release of cytokines (such as chemokines, interferons, or interleukins) in the body from an aggressive, pro-inflammatory immune response resulting from overreaction of the immune system (as to an infectious disease or immunotherapy)
Cytokines are messengers that normally help the body's immune system. But in a cytokine storm far too many are released, and they wind up killing both healthy and diseased cells. Mark Johnson
… a cytokine storm is an SOS signal that causes the immune system to launch its entire arsenal of weapons all at once. This last-ditch, kamikaze attack hurts the virus. But it leaves behind tons of collateral damage. Blood vessels take the brunt of it. Michaeleen Doucleff
see also cytokine storm syndrome

Examples of cytokine storm in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
The scientists proposed that anti-inflammatory compounds in licorice, such as flavonoids, might have helped calm the cytokine storm in the study participants, leading to better health outcomes. Dan Perry, Newsweek, 2 Jan. 2025 However, in some patients, the body releases too many cytokines, creating a cytokine storm—resulting in too much inflammation and potentially severe side effects such as lung problems and damage to other organs. Dan Perry, Newsweek, 2 Jan. 2025

Word History

First Known Use

1992, in the meaning defined above

Time Traveler
The first known use of cytokine storm was in 1992

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Cite this Entry

“Cytokine storm.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cytokine%20storm. Accessed 11 Mar. 2025.

Medical Definition

cytokine storm

noun
: the uncontrolled, sometimes life-threatening, excessive release of cytokines (as chemokines, interferons, or interleukins) in the body from an aggressive, pro-inflammatory immune response resulting from overreaction of the immune system (as to an infectious disease or immunotherapy)
Glucocorticoids have been used widely for cytokine storm and respiratory failure in patients with Covid-19; however, there is concern that they may prolong viral shedding and lead to secondary infections. David A. Berlin et al., The New England Journal of Medicine
The dead had heavier loads of the virus in more tissues and showed clearer signs of a "cytokine storm"—a lethal overreaction of the immune system. Debora MacKenzie, New Scientist
see also cytokine storm syndrome
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